Genomics Working Group of the All of Us Research Program Advisory Panel

Purpose

As a working group of the All of Us Research Program Advisory Panel, the Genomics Working Group provided information on the available options for All of Us to consider as it develops a comprehensive genomics strategy. Deliberations addressed the rapidly evolving nature of genome sequencing and variant annotation technologies and considered the program’s commitment to the return of information to participants.

Deliverables

The Genomics Working Group prepared a report for the All of Us Research Program Advisory Panel to consider as the program develops a comprehensive genomics strategy. The report provides information on the pros and cons of different approaches and options for corresponding implementation plans, and encompasses effective strategies to generate, analyze, and manage genomic data at the scale of All of Us. Recommendation of approaches for the responsible return of genetic results were not within the scope of this group but will be considered in the context of the genomics strategy.

Read the report of the Genomics Working Group pdf | 301.48 KB.

The mission of the All of Us Research Program is to accelerate health research and medical breakthroughs by partnering with 1 million or more participants across the United States to provide the most diverse biomedical data resource in history. Participants will complete surveys about their lifestyle, health, and environment; share data from their electronic health records; undergo physical measurements; and provide biospecimens. They may also contribute other biometric or lifestyle data. All of Us will generate genomic data on 1 million or more participants, although the details about timing and scale remain to be fully established. In addition, All of Us will provide access to results, including genetic/genomic information, to participants according to their preferences.

Roster

Co-chairs:

Lon Cardon, Ph.D., Chief Scientific Officer, BioMarin Pharmaceutical

Debbie Nickerson, Ph.D., Professor of Genome Sciences, University of Washington

Members:

Gonçalo Abecasis, D.Phil., Chair, Department of Biostatistics, University of Michigan

Wendy Chung, M.D., Ph.D., Associate Professor of Pediatrics, Columbia University

Joshua Denny, M.D., Associate Professor of Medicine, Vanderbilt University School of Medicine

Caroline Fox, M.D., M.P.H., Vice President and Head, Human Genetics and Pharmacogenomics, Merck Research Laboratories

Eric Green, M.D., Ph.D., Director, National Human Genome Research Institute

Joel Hirschhorn, M.D., Ph.D., Professor of Pediatrics and Professor of Genetics, Boston Children’s Hospital

Howard Jacob, Ph.D., Executive Vice President, HudsonAlpha Institute for Biotechnology

Sekar Kathiresan, M.D., Director, Cardiovascular Disease Initiative, Eli and Edythe L. Broad Institute of MIT and Harvard

Eimear Kenny, Ph.D., Assistant Professor of Genetics and Genome Sciences, Icahn School of Medicine at Mount Sinai

Christopher O’Donnell, M.D., Chief of Cardiology, VA Boston Healthcare System

Brad Ozenberger, Ph.D., Program Director, All of Us Research Program, National Institutes of Health

Heidi Rehm, Ph.D., Director, Laboratory for Molecular Medicine, Partners HealthCare

Jay Shendure, M.D., Ph.D., Associate Professor of Genome Sciences, University of Washington

Alan Shuldiner, M.D., Vice President of Translational Genetics, Regeneron Pharmaceuticals, Inc.

Karl Surkan, Ph.D., Lecturer, Massachusetts Institute of Technology

Sharon Terry, President and Chief Executive Officer, Genetic Alliance