Institutional Review Board (IRB) of the All of Us Research Program

As a single IRB, the All of Us IRB is charged with reviewing the protocol, informed consent, and other participant-facing materials for the All of Us Research Program. The IRB follows the regulations and guidance of the Office for Human Research Protections for all studies, ensuring that the rights and welfare of research participants are overseen and protected uniformly. 

IRB 101

What is an IRB?

An IRB, or Institutional Review Board, is responsible for reviewing and approving research to ensure that the rights and welfare of human participants are protected.

What is a participant?

Federal regulations define a participant, or human subject, as “a living individual about whom an investigator (whether professional or student) conducting research obtains (1) data through intervention or interaction with the individual, or (2) identifiable private information.”

How does the All of Us IRB fit in with the All of Us Research Program?

Before the program could begin to recruit and enroll participants, the All of Us IRB had to approve the All of Us protocol and materials.

All of Us IRB Members

The All of Us IRB is composed of representatives with diverse backgrounds, expertise, and perspectives.

Remembering Dr. Loretta Jones

The All of Us community mourns the recent passing of Loretta Jones, Th.D., M.A., a member of the All of Us Research Program’s institutional review board (IRB).

Dr. Jones devoted her career to improving health care access for underserved communities. In 1992, she founded Healthy African American Families, which focuses on health issues facing Los Angeles County communities of color, including diabetes and depression. She was also Associate Director of the UCLA Clinical and Translational Science Institute, which combines laboratory science with clinical and community experience to shape practical medical care.  

Dr. Jones was committed to making underserved communities and academic researchers true partners in research and ensuring that those partnerships helped reduce health disparities. These commitments led her to co-develop a model for giving underserved communities a bigger role in planning and carrying out academic research.

IRB members will remember Dr. Jones as a tireless supporter of both the All of Us Research Program and the communities she served, said Nancy E. Kass, Sc.D., IRB Chair, Vice Provost for Graduate and Professional Education, and Phoebe R. Berman Professor of Bioethics and Public Health at Johns Hopkins University.

“She was often bringing to the IRB’s attention an anecdote from a recent conversation she’d had at a community meeting, or something she’d heard when she was listening to others, that changed our direction,” said Dr. Kass, who recalled Dr. Jones’s desire that the program be responsive and accessible to a wide range of people. “We will all miss her, the questions she asked at just the right time, and the commitment she brought to speaking for those who weren’t at the table,” Dr. Kass added.

Members of the Institutional Review Board