Research Highlights

All of Us is shaping how we understand health and disease. Research Highlights showcase the recent research powered by All of Us data and tools. 

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Cartoon of two people of different race or ethnicity, age, and gender, in front of a DNA double helix. A map of the world is displayed in the background. The Logo of the All of Us Research Program is located in the lower right corner, below the text “Making Disease Risk Scores Work for More Ancestries.”

Exploring Polygenic Risk Scores Using All of Us

Polygenic risk scores are a measure of how likely you are to get a particular health condition—your risk—based on changes in many genes in your DNA. However, these scores are often most accurate for people of European ancestry, because past research left out many other groups. Researchers adjusted polygenic risk scores for 10 common conditions using the diverse genetic data in All of Us so that the scores are accurate for people from a variety of backgrounds.

A cartoon illustration of a person walking with an umbrella in a rainstorm with lightening overhead. The umbrella is labeled “Resilience,” and under the umbrella the person walks in sunlight. Logo of the All of Us Research Program.

All of Us Data Shows the Effect of Resilience in Difficult Times

A study of All of Us survey data confirmed that feelings of depression increased during the COVID-19 pandemic, particularly among participants who experienced discrimination. Having a high level of resilience lessened the effect of discrimination on mental health in some racial and ethnic groups.


Learning About the Health of Young Cancer Survivors With All of Us

The long-term health of teens and young adults who have had cancer has not been well studied. A look at All of Us data showed that young cancer survivors were more likely to have certain brain- and nerve-related conditions than participants who never had cancer. This age group may need unique treatment and management plans.